Trifluoroacetic acid → HCID 59544189, compound

Participants

Reaction Steps

To a solution of tert-butyl 2-pentafluoroethylquinoline-6-carboxylate (165 mg, 0.475 mmol) in dichloromethane (5 mL), cooled to 0° C., was added trifluoroacetic acid (2 mL, 26 mmol) and the reaction mixture allowed to warm to room temperature and stirred for 16 h. The reaction mixture was concentrated under reduced pressure to give the crude product, 2-pentafluoroethylquinoline-6-carboxylic acid (140 mg, 100%). 1H NMR (400 MHz, CDCl3+2drops CD3OD) δ 7.79 (1H, d), 8.26 (1H, d), 8.39 (1H, dd), 8.47 (1H, d), 8.67 (1H, d). LCMS: Retention time: 1.49 min. MS (ESI) m/z 292 (M+H)+.

Provenance & Evidence