1-(Morpholinocarbonylmethyl)piperazine → HCID 67013282, compound

HRID 2425636Notes

Reaction equation

HRID 2425636 reaction equation
[C:1]([C:5]1[C:10]([O:11][CH2:12][CH3:13])=[CH:9][C:8]([C:14]2[N:15]([C:33](Cl)=[O:34])[C@H:16]([C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=3)[C@H:17]([C:19]3[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=3)[N:18]=2)=[C:7]([O:36][CH2:37][CH3:38])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[N:39]1([C:45](=[O:53])[CH2:46][N:47]2[CH2:52][CH2:51][NH:50][CH2:49][CH2:48]2)[CH2:44][CH2:43][O:42][CH2:41][CH2:40]1>>[ClH:25].[C:1]([C:5]1[C:10]([O:11][CH2:12][CH3:13])=[CH:9][C:8]([C:14]2[N:15]([C:33]([N:50]3[CH2:51][CH2:52][N:47]([CH2:46][C:45]([N:39]4[CH2:40][CH2:41][O:42][CH2:43][CH2:44]4)=[O:53])[CH2:48][CH2:49]3)=[O:34])[C@H:16]([C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=3)[C@H:17]([C:19]3[CH:20]=[CH:21][C:22]([Cl:25])=[CH:23][CH:24]=3)[N:18]=2)=[C:7]([O:36][CH2:37][CH3:38])[CH:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 1006221-(Morpholinocarbonylmethyl)piperazineHCID 86602322HCID 86602322, compound

Product 1

HCID 67013282HCID 67013282, compound

Procedure

2-{4-[(4S,5R)-2-(4-tert-Butyl-2,5-diethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-1-morpholin-4-yl-ethanone hydrochloride was prepared from (4S,5R)-2-(4-tert-butyl-2,5-diethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 12f) and 1-morpholin-4-yl-2-piperazin-1-yl-ethanone (Oakwood Products) in an analogous manner as described in example 25. LR-MS: 750.4 [(M+H)+]

Sources & evidence

ORD record
ord-2268b2f103ee4f6f8f1c5ce1af00461c
Source dataset
uspto-grants-2011_06
Patent number
US07964724B2

Reaction notes

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