HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 4690691, compound → HCID 11621838, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 4690691 | HCID 4690691 | — |
| Reactant | (4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride | HCID 57732375 | — |
| Product | HCID 11621838 | HCID 11621838 | — |
Reaction Steps
[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(3,3,3-trifluoro-2-hydroxy-propyl)-piperazin-1-yl]-methanone hydrochloride was prepared from (4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 11) and 1,1,1-trifluoro-3-piperazin-1-yl-propan-2-ol (example 18b) in an analogous manner as described in example 25. LR-MS: 691.4 [(M+H)+]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964724B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-5d3c0bd47e9640ba8bbcedc1d4687930 |
| Source note | uspto-grants-2011_06 |