HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,3,3-Trifluoropropyl)piperazine → HCID 11693319, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,3,3-Trifluoropropyl)piperazine | HCID 22281413 | — |
| Reactant | (4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride | HCID 57732375 | — |
| Product | HCID 11693319 | HCID 11693319 | — |
Reaction Steps
[(4S,5R)-2-(4-tert-Butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(3,3,3-trifluoro-propyl)-piperazin-1-yl]-methanone hydrochloride was prepared from (4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 11) and 1-(3,3,3-trifluoro-propyl)-piperazine (example 16i) in an analogous manner as described in example 25. LR-MS: 675.4 [(M+H)+]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964724B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-275143bb22604b539d6bfe949842169b |
| Source note | uspto-grants-2011_06 |