N-(2-methoxy-1-methylethyl)-2-piperazin-1-yl-acetamide dihydrochloride → 2-{4-[(4S,5R)-2-[5-Chloro-4-(cyano-dimethyl-methyl)-2-ethoxy-phenyl]-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-(2-methoxy-1-methyl-ethyl)-acetamide

Participants

Role	Name	HCID	Charge
Reactant	N-(2-methoxy-1-methylethyl)-2-piperazin-1-yl-acetamide dihydrochloride	HCID 67245894	—
Reactant	(4S,5R)-2-[5-Chloro-4-(cyano-dimethyl-methyl)-2-ethoxy-phenyl]-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 86602328	—
Product	2-{4-[(4S,5R)-2-[5-Chloro-4-(cyano-dimethyl-methyl)-2-ethoxy-phenyl]-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-(2-methoxy-1-methyl-ethyl)-acetamide	HCID 11571328	—

Reaction Steps

2-{4-[(4S,5R)-2-[5-Chloro-4-(cyano-dimethyl-methyl)-2-ethoxy-phenyl]-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-(2-methoxy-1-methyl-ethyl)-acetamide was prepared from (4S,5R)-2-[5-Chloro-4-(cyano-dimethyl-methyl)-2-ethoxy-phenyl]-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 12k) and N-(2-methoxy-1-methylethyl)-2-piperazin-1-yl-acetamide (example 15) in an analogous manner as described in example 25. LR-MS: 753.4 [(M+H)+]

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07964724B2
Source dataset	uspto-grants-2011_06
ORD ID	ord-c2f4e967cfcd4a11b34ba8e7ae4fe203
Source note	uspto-grants-2011_06