1-(Morpholinocarbonylmethyl)piperazine → HCID 69459604, compound

HRID 2425713Notes

Reaction equation

HRID 2425713 reaction equation
C(C1C=CC(C2N(C(Cl)=O)[C@H](C3C=CC(Cl)=CC=3)[C@H](C3C=CC([Cl:22])=CC=3)N=2)=C(OCC(F)(F)F)C=1)(C)(C)C.[N:39]1([C:45](=[O:53])[CH2:46]N2CCNCC2)[CH2:44][CH2:43][O:42][CH2:41][CH2:40]1>>[ClH:22].[N:39]1([C:45](=[O:53])[CH3:46])[CH2:44][CH2:43][O:42][CH2:41][CH2:40]1

Participants

3

Reactant 2

HCID 1006221-(Morpholinocarbonylmethyl)piperazineHCID 86761342HCID 86761342, compound

Product 1

HCID 69459604HCID 69459604, compound

Procedure

(4S,5R)-2-[4-tert-butyl-2-(2,2,2-trifluoro-ethoxy)-phenyl]-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-1-morpholin-4-yl-ethanone hydrochloride was prepared from (4S,5R)-2-[4-tert-butyl-2-(2,2,2-trifluoro-ethoxy)-phenyl]-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 12l) and 1-morpholin-4-yl-2-piperazin-1-yl-ethanone (Oakwood Products) in an analogous manner as described in example 25. LR-MS: 760.5 [(M+H)+]

Sources & evidence

ORD record
ord-fdcc76a288f649f18f51c1435a0b5fb9
Source dataset
uspto-grants-2011_06
Patent number
US07964724B2

Reaction notes

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