Phosgene → HCID 86602331, compound

HRID 2425720Notes

Reaction equation

HRID 2425720 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[NH:11][C:10]([C:20]3[CH:25]=[CH:24][C:23]([C:26]([CH3:31])([CH3:30])[CH2:27][O:28][CH3:29])=[CH:22][C:21]=3[O:32][CH2:33][CH3:34])=[N:9]2)=[CH:4][CH:3]=1.[C:35](Cl)([Cl:37])=[O:36]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH:12]([C:13]3[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=3)[N:11]([C:35]([Cl:37])=[O:36])[C:10]([C:20]3[CH:25]=[CH:24][C:23]([C:26]([CH3:31])([CH3:30])[CH2:27][O:28][CH3:29])=[CH:22][C:21]=3[O:32][CH2:33][CH3:34])=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6371PhosgeneHCID 67244809HCID 67244809, compound

Product 1

HCID 86602331HCID 86602331, compoundYield 57%

Procedure

4,5-bis-(4-chloro-phenyl)-2-[2-ethoxy-4-(2-methoxy-1,1-dimethyl-ethyl)-phenyl]-4,5-dihydro-1H-imidazole (580 mg, 1.166 mmol) was reacted with phosgene (725 uL, 1.399 mmol, 20% solution in toluene) using the procedure as described in example 12 to give 4,5-bis-(4-chloro-phenyl)-2-[2-ethoxy-4-(2-methoxy-1,1-dimethyl-ethyl)-phenyl]-4,5-dihydro-imidazole-1-carbonyl chloride (370 mg, 57% yield) as white solids.

Sources & evidence

ORD record
ord-b1a923481eda4eff8e53fac3c770f548
Source dataset
uspto-grants-2011_06
Patent number
US07964724B2

Reaction notes

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