Methanol → HCID 86761341, compound

Participants

Reaction Steps

A solution of 1-isopropyl-5-methyl-2-oxo-N-(piperidin-4-ylmethyl)-1,2-dihydroquinoline-3-carboxamide (150 mg, 0.44 mmol, step 4 in preparation 3) and tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (112 mg, 0.53 mmol, Castro Jose L. et al., J. Med. Chem., 1998, 41, 2667) in methanol (5 mL) was heated at 80° C. overnight. After cooled to room temperature, concentrated gave yellow oil. The residue was chromatographed on a column of silica gel eluting with 25% ammonium hydroxide/methanol/dichloromethane (2/10/100) to give 111 mg (45%) of the title compound as a white solid.

Provenance & Evidence