反应详情

To a solution of 5-chloro-1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (100 mg, 0.376 mmol, step 4) in dichloromethane (1 mL) was added oxalyl chloride (0.10 mL, 1.13 mmol) and a drop of N,N-dimethylformamide at 0° C. The mixture was stirred at room temperature for 1.5 h. The solvent and excess amount of oxalyl chloride was removed in vacuo. The residue was dissolved in dichloromethane (1 mL) and [(1-butylpiperidin-4-yl)methyl]amine (128 mg, 0.753 mmol) in dichloromethane (1 mL) was added at 0° C. and the mixture was stirred at room temperature for 1 h. Then, the mixture was quenched with water (10 mL) and the aqueous layer was extracted with dichloromethane (20 mL×2). The organic layer was dried over sodium sulfate and concentrated in vacuo gave a colorless oil. The resultant oil was dissolved in 10% methanolic hydrogen chloride (5 mL) and stirred for 16 h. The formed precipitate was filtrated and washed with methanol to give 100 mg (59%) of the title compound as a white solid.

1. customat 0° C
2. customThe solvent and excess amount of oxalyl chloride was removed in vacuo
3. dissolutionThe residue was dissolved in dichloromethane (1 mL)
4. stirringthe mixture was stirred at room temperature for 1 h
5. customThen, the mixture was quenched with water (10 mL)
6. extractionthe aqueous layer was extracted with dichloromethane (20 mL×2)
7. dry with materialThe organic layer was dried over sodium sulfate
8. concentrationconcentrated in vacuo
9. customgave a colorless oil
10. stirringstirred for 16 h
11. filtrationThe formed precipitate was filtrated
12. washwashed with methanol