HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → tert-Butyl (1S,2S)-1-amino-2-ethylcyclopropane-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | (1S,2S) 2-Ethyl-1-(2trimethylsilanylethoxycarbonylamino)cyclopropane-carboxylic acid tert-butyl ester | HCID 86601847 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | tert-Butyl (1S,2S)-1-amino-2-ethylcyclopropane-1-carboxylate | HCID 86620254 | — |
Reaction Steps
To the product of Step 3 (3 g, 9 mmol) was added a 1.0M TBAF solution in THF (9.3 mL, 9.3 mmol). The mixture was heated to reflux for 1.5 hours, cooled to room temperature, and diluted with 500 mL of ethyl acetate. The solution was successively washed with water (2×100 mL) and brine (2×100 mL), dried (MgSO4), filtered, and concentrated in vacuo to provide the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07964560B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-8823f1ffef0e4f7c981c2f605032a6a4 |
| Source note | uspto-grants-2011_06 |