Trifluoroacetic acid → HCID 44140043, compound

Participants

Reaction Conditions

Reaction Steps

The reaction mixture composed of 5.8 g of (2-amino-3-methoxyphenyl)(2,6-difluorophenyl)methanol, 11 ml of triethylsilane (3 eq.), 10 ml of trifluoroacetic acid (3.9 eq.) in 90 ml of dichloromethane is heated for 6 hours at 40° C. After one night at room temperature, the reaction medium is slowly hydrolyzed in the cold state with 6N sodium hydroxide, the organic phase is dried over anhydrous sodium sulfate and concentrated. The residue is purified by filtration on silica H, eluting with dichloromethane, in order to obtain 3.8 g of the expected product.

Provenance & Evidence