1-Chloro-4-nitrobenzene → HCID 67148374, compound

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Reaction Steps

8.66 g of 4-chloronitrobenzene and 8.2 g of 2-chloromethylpyridine in solution in 100 ml of dimethyl sulfoxide are slowly added to 22.44 g of potassium tert-butoxide in 500 ml of dimethyl sulfoxide. After 18 hours at room temperature, the mixture is hydrolyzed with a saturated ammonium chloride solution and extracted three times with dichloromethane. The organic phase is dried over anhydrous sodium sulfate and concentrated. The residue is filtered on silica H (eluent dichloromethane) in order to obtain 10.695 g of the expected product.

Provenance & Evidence