Triphenylphosphine → HCID 67148390, compound

Participants

Reaction Steps

0.91 ml of diisopropylazodicarboxylate is added at room temperature to 1.21 g of triphenylphosphine in solution in 25 ml of tetrahydrofuran. After 30 minutes, 0.86 g of tert-butyl (3S)-3-hydroxypyrrolidine-1-carboxylate is introduced. After 30 minutes, 1.29 g of N-[4-chloro-2-(pyridin-2-ylmethyl)phenyl]-3,4-dimethoxybenzene-sulfonamide are added and the mixture is left for 18 hours at room temperature. The reaction medium is concentrated and chromatographed on silica gel in order to obtain 2.94 g of the expected product.

Provenance & Evidence