HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)piperidine → 6-(2-Pentynyloxy)-4-(3-trifluoromethylpiperidino)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)piperidine | HCID 2760776 | — |
| Reactant | 4-Chloro-6-(2-pentynyloxy)pyrimidine | HCID 22599770 | — |
| Product | 6-(2-Pentynyloxy)-4-(3-trifluoromethylpiperidino)pyrimidine | HCID 66594989 | 47.1% |
Reaction Steps
0.2 g of 4-chloro-6-(2-pentynyloxy)pyrimidine and 0.23 g of 3-trifluoromethylpiperidine were mixed and left for 10 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.15 g of 6-(2-pentynyloxy)-4-(3-trifluoromethylpiperidino)pyrimidine (hereinafter, referred to as Compound (25)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07968537B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-850890aafef74d6b8817c80ffd3c13d6 |
| Source note | uspto-grants-2011_06 |