反应详情

A mixture of tert-butyl 4-(3-(3,5-dichlorobenzylamino)-4-(2,2,2-trifluoroacetyl)phenyl)-piperazine-1-carboxylate (0.25 g, 0.5 mmol), trifluoroacetic acid (5 mL) and dichloromethane (10 mL) was stirred for 3 h and concentrated in vacuo. The residue was dissolved in dichloromethane; this solution was washed with aqueous NaHCO3 solution, dried over Na2SO4 and concentrated in vacuo. The yellow solid residue was dissolved in dichloromethane (1 mL), reacted with 1 N HCl in ether (1 mL) and concentrated in vacuo to yield the title compounds as a yellow solid (0.16 g, 73%). 1H NMR (400 MHz, CDCl3): δ 9.37 (br, 1H), 7.62 (d, 1H), 7.28 (s, 1H), 7.22 (s, 2H), 6.24 (dd, 1H), 5.71 (d, 1H), 4.43 (d, 2H), 3.30 (m, 4H), 2.93 (m, 4H). MS (ESI) m/z: Calculated: 431; Observed: 432 (M+H+).

1. concentrationconcentrated in vacuo
2. dissolutionThe residue was dissolved in dichloromethane
3. washthis solution was washed with aqueous NaHCO3 solution
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo
6. dissolutionThe yellow solid residue was dissolved in dichloromethane (1 mL)
7. customreacted with 1 N HCl in ether (1 mL)
8. concentrationconcentrated in vacuo