Hydrochloric Acid → HCID 86664771, compound

Participants

Reaction Steps

To a solution of N-(1-(3,5-dimethoxyphenyl)ethyl-2-(methylsulfonyl)-5-(piperazin-1-yl)-benzeneamine (500 mg, 1.19 mmol) in dichloromethane (5.0 mL) was added 1M solution of HCl in diethyl ether (25 mL). The reaction mixture was stirred for 3 h. The solvent was removed by rotary evaporation to afford the title compound (521 mg, 96% yield). 1H NMR (400 MHz, CD3OD): δ 7.55 (m, 1H), 6.57 (s, 3H), 6.36 (m, 1H), 5.49 (s, 1H), 4.61 (m, 1H), 3.75 (s, 6H), 3.41 (m, 4H), 3.25 (m, 4H), 3.18 (m, 2H), 3.21 (s, 3H), 1.55 (d, 3H); MS (ESI) m/z: Calculated for C21H30ClN3O4S: 455.16; Observed: 456.2 (M++1).

Provenance & Evidence