Hydrochloric Acid → HCID 11560746, compound

Participants

Reaction Steps

To a solution of N-(2-(methylsulfonyl)-5-(piperazin-1-yl)phenyl)naphthalen-1-amine (120.0 mg, 0.31 mmol) in dichloromethane (2 mL) was added 0.4 mL of 1 M HCl in diethyl ether. The solution was allowed to stir for 1 h, after which a precipitate formed. The solvent was removed by rotary evaporation to collect the title compound (122.0 mg, 0.29 mmol) in 94% yield. 1H NMR (400 MHz, CD3OD): δ 7.94 (d, 1H), 7.91 (d, 1H), 7.84 (d, 1H), 7.73 (d, 1H), 7.50 (m, 4H), 6.60 (d, 1H), 6.29 (s, 1H), 3.47 (m, 4H), 3.21 (m, 4H), 3.19 (s, 3H); MS (ESI) m/z: Calculated for C21H24N3O2S: 382.2; Observed: 382.4 (M++1).

Provenance & Evidence