Hydrochloric Acid → HCID 67147382, compound

Participants

Reaction Steps

A solution of 6-chloro-N-(2-(methylsulfonyl)-5-(piperazin-1-yl)phenyl)chroman-4-amine (26.0 mg, 0.06 mmol) in anhydrous dichloromethane (5 mL) was cooled to 0° C. and HCl 37 μL of a 2M solution in diethyl ether, (0.07 mmol) were added. The mixture was allowed to stir for 30 min. After removal of solvent by rotary evaporation the desired product was collected (27.0 mg, 99%). 1H NMR (400 MHz, CD3OD): δ 7.62 (d, 1H), 7.27 (d, 1H), 7.17 (dd, 1H), 6.83 (d, 1H), 6.51 (s, 1H), 6.48 (s, 1H), 4.89 (m, 1H), 4.25 (m, 2H), 3.59 (m, 4H), 3.34 (m, 4H), 2.98 (s, 3H), 2.16 (m, 2H); MS (ESI) m/z: 422.0 (M++1).

Provenance & Evidence