Diethyl Ether → HCID 58707339, compound

Participants

Reaction Steps

To a solution of 1-(5-Fluoro-2-methoxy-3-chlorophenyl)ethanol (2.1 g 10.1 mmol) in acetone (30 mL) at room temperature was added pyridinium chlorochromate (5.5 g, 26.2 mmol). The reaction was stirred for 3 hours, diethyl ether was added (50 mL). The resultant sludge was filtered through celite. The organic phase was dried over Na2SO4, filtered over silica gel, and concentrated to the crude compound which was purified by silica gel column (20% ethyl acetate in hexanes) to afford 1-(5-fluoro-2-methoxy-3-chlorophenyl)ethanone (1.9 g, 97%): 1H NMR (400 MHz, CDCl3): δ 7.24 (m, 2H), 3.84 (s, 3H), 2.63 (s, 3H).

Provenance & Evidence