Carbon Dioxide → HCID 67147345, compound

Participants

Reaction Steps

(1-(5-Fluoro-2-methoxy-3-methylphenyl)ethyl)-2-(methylsulfonyl)-5-(piperazin-1-yl)benzenamine (60 mg, 0.14 mmol) was dissolved in dichloromethane (1.5 mL). The solution was cooled in a bath with dry ice and methanol. Hydrochloric acid (1.0 mL, 2.0 M in ether) was added slowly. The mixture was warmed to room temperature. The precipitate was filtered and washed with diethyl ether gave (1-(5-Fluoro-2-methoxy-3-methylphenyl)ethyl)-2-(methylsulfonyl)-5-(piperazin-1-yl)benzenamine hydrochloride salt as a white solid (52 mg, 81%): 1H NMR (400 MHz, CD3OD): 1H NMR (400 MHz, CD3OD): δ 7.71 (d, 1H), 6.94 (dd, 1H), 6.85 (dd, 1H), 6.59 (d, 1H), 6.39 (dd, 1H), 4.95 (bs, 3H), 4.88 (m, 1H), 3.79 (s, 3H), 3.34-3.15 (m, 4H), 3.15 (s, 3H), 2.98 (m, 4H), 2.32 (s, 3H), 1.49 (d, 3H). MS (ESI) m/z: Calculated: 421.18; Observed: 422.2 (M+H+); (C21H28FN3O3S.HCl).

Provenance & Evidence