Hydrochloric Acid → N-(1-(3,5-Dichlorophenyl)ethyl)-2-nitro 5-(piperazin-1-yl)-benzeneamine hydrochloride

Participants

Reaction Steps

To a solution of N-(1-(3,5-dichlorophenyl)ethyl)-2-nitro-5-(piperazin-1-yl)benzeneamine (0.09 mmol) in dichloromethane (2.0 mL) was added a saturated solution of HCl in diethyl ether (15 mL). The reaction mixture was stirred for 2 h. The solvent was removed by rotary evaporation to afford the title compound in 39% yield. 1H NMR (400 MHz, CD3OD): δ 7.67 (d, 1H), 7.37 (s, 2H), 7.35 (s, 1H), 6.41 (d, 1H), 5.84 (s, 1H), 4.79 (m, 1H), 3.57 (m, 4H), 3.25 (m, 4H), 1.61 (d, 3H); MS (ESI) m/z: Calculated for C18H20Cl2N4O2.HCl: 431.74; Observed: 396.4 (M++1 corresponding to its free base).

Provenance & Evidence