反应详情

5-Amino-3-methyl-1H-pyrazole-4-carbonitrile (15.0 g, above) was added to stirred concentrated sulfuric acid (47 mL, 95%) cooled with cold water bath. After the addition, the reaction mixture was stirred at room temperature for 2 hours before it was poured with stirring into a mixture of ice and water. The precipitate was collected by filtration, washed with cold water to remove excess sulfuric acid, and dried in a vacuum desiccator to give 5-amino-3-methyl-1H-pyrazole-4-carboxylic acid amide. (Yield 19.6 g).

1. temperaturecooled with cold water bath
2. additionAfter the addition
3. additionwas poured
4. filtrationThe precipitate was collected by filtration
5. washwashed with cold water
6. customto remove excess sulfuric acid
7. customdried in a vacuum desiccator