Sulfuric Acid → HCID 178434679, compound

HRID 2426102Notes

Reaction equation

HRID 2426102 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]#[N:9].S(=O)(=O)(O)[OH:11]>O>[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]([NH2:9])=[O:11]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 178434678HCID 178434678, compound

Product 1

HCID 178434679HCID 178434679, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5-Amino-3-methyl-1H-pyrazole-4-carbonitrile (15.0 g, above) was added to stirred concentrated sulfuric acid (47 mL, 95%) cooled with cold water bath. After the addition, the reaction mixture was stirred at room temperature for 2 hours before it was poured with stirring into a mixture of ice and water. The precipitate was collected by filtration, washed with cold water to remove excess sulfuric acid, and dried in a vacuum desiccator to give 5-amino-3-methyl-1H-pyrazole-4-carboxylic acid amide. (Yield 19.6 g).

Workup

  1. temperaturecooled with cold water bath
  2. additionAfter the addition
  3. additionwas poured
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with cold water
  6. customto remove excess sulfuric acid
  7. customdried in a vacuum desiccator

Sources & evidence

ORD record
ord-53df185db8b54327bf2e032e5cdc2f97
Source dataset
uspto-grants-2011_06
Patent number
US07968554B2

Reaction notes

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