HCID 57426190, compound → HCID 57426196, compound

HRID 2426195Notes

Reaction equation

HRID 2426195 reaction equation
[C:1]([O:5][C:6](=[O:23])[CH2:7][N:8]1[C:16]2[C:11](=[C:12]([N+:17]([O-])=O)[CH:13]=[CH:14][CH:15]=2)[C:10]([CH2:20][C:21]#[N:22])=[CH:9]1)([CH3:4])([CH3:3])[CH3:2]>CCO.[Pd]>[C:1]([O:5][C:6](=[O:23])[CH2:7][N:8]1[C:16]2[C:11](=[C:12]([NH2:17])[CH:13]=[CH:14][CH:15]=2)[C:10]([CH2:20][C:21]#[N:22])=[CH:9]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 57426190HCID 57426190, compound2×

Product 1

HCID 57426196HCID 57426196, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of tert-butyl[3-(cyanomethyl)-4-nitro-1H-indol-1-yl]acetate (700 mg, 2.22 mmol, described in Intermediate 46) and 10% Pd/C (65 mg) in EtOH (20 mL) was stirred under an atmosphere of hydrogen (ca. 1 atm). After 4 h, the reaction was filtered through a Celite pad and concentrated in vacuo to give the title compound. MS: m/z=286 (M+1).

Workup

  1. filtrationthe reaction was filtered through a Celite pad
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-93cd43b370c947d691317f7275730500
Source dataset
uspto-grants-2011_06
Patent number
US07968540B2

Reaction notes

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