Ethyl Acetate → HCID 86635773, compound

Participants

Reaction Steps

A mixture of methyl (3-{[(7R)-3′-methyl-2′,5′-dioxo-6,8-dihydrospiro[cyclopenta[g]quinoline-7,4′-imidazolidin]-2-yl]methyl}-7-nitro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)acetate from Step A (143 mg, 0.27 mmol) and 10% Pd/C (20 mg) was stirred vigorously in MeOH (3 mL) and EtOAc (5 mL) under an atmosphere of hydrogen (ca. 1 atm). Additional amounts of 10% Pd/C (20 mg) were added after 16 h and 24 h. After a total reaction time of 96 h, the mixture was filtered through a pad of Celite, washing with MeOH, and the filtrate was concentrated in vacuo to give the title compound in sufficient purity for use in the next step. MS: m/z 501 (M+1).

Provenance & Evidence