HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2426257Generated: October 28, 2026
4-Fluorobenzylamine → N-[(4-fluorophenyl)methyl]-3-hydroxy-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidine-2-carboxamide
https://huagongshe.com/reaction/2426257
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Fluorobenzylamine | HCID 67326 | — |
| Reactant | methyl 3-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate | HCID 59771070 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-[(4-fluorophenyl)methyl]-3-hydroxy-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidine-2-carboxamide | HCID 54688265 | — |
Reaction Steps
A solution of methyl 3-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate obtained in Step 3b or Step 5a and 4-fluoro-benzylamine (2 eq.) in methanol was stirred and heated to 65° C. for 22 h. The solvent was removed under reduced pressure and the title product was obtained by preparative RP-HPLC, using water (0.1% TFA) and acetonitrile (0.1% TFA) as eluents (column: C18). The pooled product fractions were lyophilized to afford the title compound as a fluffy white material.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07968553B2 |
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| Source dataset | uspto-grants-2011_06 |
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| ORD ID | ord-7e1183715f4945f581d10b78d45b6097 |
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| Source note | uspto-grants-2011_06 |
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