Phosphoric Acid → HCID 18694752, compound

HRID 2426270Notes

Reaction equation

HRID 2426270 reaction equation
[OH:1]P(O)(O)=O.[ClH:6].[N:7]1[CH:12]=[CH:11][CH:10]=[N:9][CH:8]=1.C[C:14]#[N:15]>>[ClH:6].[N:7]1[CH:12]=[CH:11][CH:10]=[N:9][C:8]=1[C:14]([NH2:15])=[O:1]

Participants

4

Reactant 3

HCID 1004Phosphoric AcidHCID 6342Acetonitrile3×HCID 21910562HCID 21910562, compound

Product 1

HCID 18694752HCID 18694752, compound

Procedure

HPLC conditions: Column: Zorbax, Rx C8 250×4.6 mm; Temperature: 30° C.; Detection at 210 nm; Mobile Phase: 0.1% aq H3PO4 (A)/MeCN (B); Gradient: 90:10 (A)/(B) to 10:90 over 15 min, 10:90 hold for 5 min, 10:90 to 90:10 (A)/(B) over 10 seconds; Flow Rate: 1 mL/min. Retention time: the seven-membered ring-pyrimidine hydrochloride salt 11—8.118 minutes.

Workup

  1. custom30° C.

Sources & evidence

ORD record
ord-9e431056f5474f35989954d327e6426d
Source dataset
uspto-grants-2011_06
Patent number
US07968553B2

Reaction notes

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