HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-Amino-5-bromo-2-chloropyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 5-Bromo-2,4-dichloropyrimidine | HCID 289973 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Amino-5-bromo-2-chloropyrimidine | HCID 2763293 | — |
Reaction Steps
A solution of 5-bromo-2,4-dichloropyrimidine (25g, 110 mmol) in 200 mL THF is treated with 47 mL of ammonia (330 mmol, 7.0M solution in methanol). After stirring for 15 hours the solution is concentrated under reduced pressure and purified by short-filtration (SiO2, Hexanes: Ethyl acetate/1:1) to yield 21g (92%) of 1 as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07968557B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-1b57774ad68d496e8aeb25ca9f49d7c5 |
| Source note | uspto-grants-2011_06 |