反应详情

温度

25 °C

To a solution of 4-hydroxymethyl-3-isopropylphenyl 1,1,1-trifluoromethanesulfonate (Intermediate 149, 190.0 mg, 0.64 mmol) in 5 mL CH2Cl2 was added acetyl chloride (75.0 mg, 0.96 mmol) and pyridine(101.0 mg, 1.38 mmols). After stirring for 3 hours at 25° C. the reaction was quenched by the addition of H2O and the resulting mixture extracted with EtOAc. The combined organic layers were washed with H2O and saturated aqueous NaCl, dried (MgSO4) and concentrated under reduced pressure. The title compound, 182 mg (84%), was isolated from the residual oil by column chromatography (5-10% EtOAc—hexanes) as a colorless oil.

1. customwas quenched by the addition of H2O
2. extractionthe resulting mixture extracted with EtOAc
3. washThe combined organic layers were washed with H2O and saturated aqueous NaCl
4. dry with materialdried (MgSO4)
5. concentrationconcentrated under reduced pressure