Thiazolidinedione → HCID 86606236, compound

HRID 2426302Notes

Reaction equation

[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]([CH2:15][N:16]([CH3:25])[C:17](=[O:24])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH:12]=[N:13][CH:14]=2)=[CH:5][CH:4]=1)=O.[S:26]1[CH2:30][C:29](=[O:31])[NH:28][C:27]1=[O:32]>>[O:32]=[C:27]1[NH:28][C:29](=[O:31])[C:30](=[CH:1][C:3]2[CH:4]=[CH:5][C:6]([C:9]3[CH:10]=[C:11]([CH2:15][N:16]([CH3:25])[C:17](=[O:24])[C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH:12]=[N:13][CH:14]=3)=[CH:7][CH:8]=2)[S:26]1

Participants

Reactant 2

HCID 5437Thiazolidinedione

HCID 86017449HCID 86017449, compound

Product 1

HCID 86606236HCID 86606236, compoundYield 60%

Procedure

In a manner similar to that of Example 1(d), starting with 0.8 g (2.4 mmol) of N-[5-(4-formylphenyl)pyrid-3-ylmethyl]-N-methylbenzamide and 0.35 g (2.9 mmol) of 2,4-thiazolidinedione, 0.6 g (60%) of N-{5-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)phenyl]pyrid-3-ylmethyl}-N-methylbenzamide is obtained.

Sources & evidence

ORD record: ord-39ab54eb955049d5951ff0cea7cd1dfb
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07968560B2

Reaction notes

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