反应详情

A solution of (4-amino-1-isobutyl-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-2-yl)methanol (1.95 g, 7.85 mmol) and thionyl chloride (1.72 mL, 23.6 mmol) in chloroform (80 mL) was heated at reflux for 2 hours. The solvent was removed under reduced pressure and the residue triturated with chloroform to give 1.53 g of 2-(chloromethyl)-1-isobutyl-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-4-amine hydrochloride as an off-white powder.

1. temperatureat reflux for 2 hours
2. customThe solvent was removed under reduced pressure
3. customthe residue triturated with chloroform