HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 4-(3-Bromo-1H-indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 4-(1H-Indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one | HCID 135687553 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-(3-Bromo-1H-indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one | HCID 135525544 | — |
Reaction Steps
22 mg 4-(1H-Indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one is suspended in 30 mL acetone and 2 mg N-bromosuccinimide is added. The reaction mixture is stirred for 3 hours at room temperature, the precipitated product isolated by filtration and washed with acetone. The product is purified by preparative RP-HPLC eluting with a gradient of 0-100% acetonitrile in water (0.05% HCOOH). Yield 11.2 mg. LC-MS (ES+) 368 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07968546B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-4c7b201a397f4456a981424a9a17936e |
| Source note | uspto-grants-2011_06 |