Sodium Hydroxide → HCID 135508253, compound

HRID 2426516Notes

Reaction equation

HRID 2426516 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([C:13]1[CH:18]=[C:17]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)[N:16]=[N:15][C:14]=1[O:25]C)=[CH:7]2)([CH3:3])[CH3:2].[OH-].[Na+]>CCO>[CH:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([C:13]1[C:14](=[O:25])[NH:15][N:16]=[C:17]([C:19]3[CH:20]=[CH:21][N:22]=[CH:23][CH:24]=3)[CH:18]=1)=[CH:7]2)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 23092494HCID 23092494, compound

Product 1

HCID 135508253HCID 135508253, compoundYield 11%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
150 °C

Procedure

To a solution of 139 mg (crude material) 5-isopropyl-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-1H-indole in 2.5 ml EtOH is added 2.5 ml aq. NaOH (1 M). The mixture is heated for 10 min at 150° C. using microwave. After cooling to room temperature the mixture is filtered and purified by HPLC to give 14 mg (11%) of the desired product as yellow solid.

Workup

  1. temperatureAfter cooling to room temperature the mixture
  2. filtrationis filtered
  3. custompurified by HPLC

Sources & evidence

ORD record
ord-cf7141943f14444db4d694a15aec944a
Source dataset
uspto-grants-2011_06
Patent number
US07968546B2

Reaction notes

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