反应详情

温度

50 °C

4 mg acetyl chloride are added at 0° C. to a suspension of 80 mg aluminum chloride 1,2-Dichloroethane, followed by 208 mg 2-(3-Methoxy-6-pyridin-4-yl-pyridazin-4-yl)-1H-indole Trifluoroacetate. The reaction mixture is stirred for 4 h at room temperature and for 3 h at 50° C. It is worked up pouring into an ice/water mixture and filtering. The layers are separated, the organic layer is washed with water, dried over MgSO4 and the solvent removed. Reverse phase HPLC chromatography yielded 8.1 mg 4-(3-Acetyl-1H-indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one.

1. filtrationfiltering
2. customThe layers are separated
3. washthe organic layer is washed with water
4. dry with materialdried over MgSO4
5. customthe solvent removed