N-Iodosuccinimide → 4-(3-Iodo-1H-indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one

HRID 2426526Notes

Reaction equation

HRID 2426526 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]1[C:11](=[O:22])[NH:12][N:13]=[C:14]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH:15]=1.C1C(=O)N([I:30])C(=O)C1>CC(C)=O>[I:30][C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][C:2]=1[C:10]1[C:11](=[O:22])[NH:12][N:13]=[C:14]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH:15]=1

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 1356875534-(1H-Indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one

Product 1

HCID 1354144544-(3-Iodo-1H-indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

577 mg 4-(1H-Indol-2-yl)-6-pyridin-4-yl-2H-pyridazin-3-one is suspended in 30 mL acetone and 550 mg NIS is added. The reaction mixture is stirred for 3 hours at room temperature, the precipitated product isolated by filtration and washed with acetone. The material product is used without further purification

Workup

  1. customthe precipitated product isolated by filtration
  2. washwashed with acetone
  3. customThe material product is used without further purification

Sources & evidence

ORD record
ord-b084605c1d9b43cf8c5f4929868e9465
Source dataset
uspto-grants-2011_06
Patent number
US07968546B2

Reaction notes

Loading…