5-Bromo-2-furanecarboxylic acid → 5-Bromofuran-2-carboxylic Acid [4-(3-dimethylaminopyrrolidin-1-yl)phenyl]amide

HRID 2426658Notes

Reaction equation

HRID 2426658 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]([CH3:15])[CH3:14])[CH2:9]2)=[CH:4][CH:3]=1.[Br:16][C:17]1[O:21][C:20]([C:22](O)=[O:23])=[CH:19][CH:18]=1>>[CH3:14][N:13]([CH3:15])[CH:10]1[CH2:11][CH2:12][N:8]([C:5]2[CH:6]=[CH:7][C:2]([NH:1][C:22]([C:20]3[O:21][C:17]([Br:16])=[CH:18][CH:19]=3)=[O:23])=[CH:3][CH:4]=2)[CH2:9]1

Participants

3

Reactant 2

HCID 685115-Bromo-2-furanecarboxylic acidHCID 219165911-(4-aminophenyl)-N,N-dimethylpyrrolidin-3-amine

Product 1

HCID 671477595-Bromofuran-2-carboxylic Acid [4-(3-dimethylaminopyrrolidin-1-yl)phenyl]amide

Procedure

[1-(4-Aminophenyl)pyrrolidin-3-yl]dimethylamine was reacted with 5-bromo-2-furancarboxylic acid by method E. The product with a molecular weight of 378.27 (C17H20BrN3O2); MS (ESI): 379 (M+H+) was obtained as hydrotrifluoroacetate.

Workup

  1. customMS (ESI): 379 (M+H+) was obtained as hydrotrifluoroacetate

Sources & evidence

ORD record
ord-e6a45e37ef5a4ac8b6a8b36c332472f5
Source dataset
uspto-grants-2011_06
Patent number
US07968550B2

Reaction notes

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