HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(2,4-difluorophenyl)benzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 21105541 | HCID 21105541 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | 4-(2,4-difluorophenyl)benzoic Acid | HCID 2758264 | — |
Reaction Steps
0.098 ml of 1 N lithium hydroxide solution was added to a solution of 0.051 g of ethyl 2′,4′-difluorobiphenyl-4-carboxylate in 1ml THF/water (1:1), and the mixture was stirred at room temperature overnight. 5% hydrochloric acid was used to neutralize the solution, which was concentrated in vacuo, and the residue was purified by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07968550B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-dfd4be6021e44ba49211f4f7b95232dd |
| Source note | uspto-grants-2011_06 |