2-Chloro-5-fluoropyridine → N-[4-(3-Dimethylaminopyrrolidin-1-yl)phenyl]-4-(5-fluoropyridin-2-yloxy)benzamide

HRID 2426690Notes

Reaction equation

HRID 2426690 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][N:3]=1.[CH3:9][N:10]([CH3:32])[CH:11]1[CH2:15][CH2:14][N:13]([C:16]2[CH:21]=[CH:20][C:19]([NH:22][C:23](=[O:31])[C:24]3[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][CH:25]=3)=[CH:18][CH:17]=2)[CH2:12]1>>[CH3:9][N:10]([CH3:32])[CH:11]1[CH2:15][CH2:14][N:13]([C:16]2[CH:17]=[CH:18][C:19]([NH:22][C:23](=[O:31])[C:24]3[CH:25]=[CH:26][C:27]([O:30][C:2]4[CH:7]=[CH:6][C:5]([F:8])=[CH:4][N:3]=4)=[CH:28][CH:29]=3)=[CH:20][CH:21]=2)[CH2:12]1

Participants

3

Reactant 2

HCID 27828012-Chloro-5-fluoropyridineHCID 21105609N-[4-(3-dimethylaminopyrrolidin-1-yl)phenyl]-4-hydroxybenzamide

Product 1

HCID 21105608N-[4-(3-Dimethylaminopyrrolidin-1-yl)phenyl]-4-(5-fluoropyridin-2-yloxy)benzamide

Procedure

2-Chloro-5-fluoropyridine was reacted with N-[4-(3-dimethylaminopyrrolidin-1-yl)phenyl]-4-hydroxybenzamide by method R. This resulted in the product with the molecular weight of 420.2 (C24H25FN4O2); MS (ESI): 421 (M+H+) as hydrotrifluoroacetate.

Workup

  1. customThis resulted in the product with the molecular weight of 420.2 (C24H25FN4O2)

Sources & evidence

ORD record
ord-5ffb7e38321d4320ac1b4695b406c33f
Source dataset
uspto-grants-2011_06
Patent number
US07968550B2

Reaction notes

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