HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → tert-Butyl (R)-[1-(2-fluoro-4-isopropylaminophenyl)pyrrolidin-3-yl]methylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Triacetoxyborohydride | HCID 2724942 | — |
| Reactant | tert-Butyl (R)-[1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamate | HCID 68988249 | — |
| Product | tert-Butyl (R)-[1-(2-fluoro-4-isopropylaminophenyl)pyrrolidin-3-yl]methylcarbamate | HCID 86594881 | — |
Reaction Steps
tert-Butyl (R)-[1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamate was alkylated with acetone using triacetoxyborohydride as reducing agent by method N. This resulted in the product with the molecular weight of 351.47 (C19H30FN3O2); MS (ESI): 352 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07968550B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-3f992da50c404921844e9bd4e66457b0 |
| Source note | uspto-grants-2011_06 |