Potassium Hydroxide → HCID 21105435, compound

HRID 2426735Notes

Reaction equation

HRID 2426735 reaction equation
[OH-].[K+].[F:3][C:4]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:5]=1[O:6][C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=[O:12])=[CH:9][CH:8]=1>C1COCC1.O>[F:3][C:4]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:5]=1[O:6][C:7]1[CH:8]=[CH:9][C:10]([C:11]([OH:13])=[O:12])=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 18695463HCID 18695463, compound

Product 1

HCID 21105435HCID 21105435, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Conditions

Temperature
110 °C

Procedure

0.518 g of potassium hydroxide was added to a solution of 0.428 g of ethyl 4-(2,4-difluorophenoxy)benzoate in 2 ml of THF/water (1:1). The solution was heated at 110° C. for 6 hours. The THF was then removed in vacuo, and the aqueous phase was freeze dried and purified by preparative HPLC. This resulted in the product with the molecular weight of 250.04 (C13H8F2O3); MS (ESI): 251 (M+H+).

Workup

  1. customThe THF was then removed in vacuo
  2. customdried
  3. custompurified by preparative HPLC
  4. customThis resulted in the product with the molecular weight of 250.04 (C13H8F2O3)

Sources & evidence

ORD record
ord-2ae9e14abee64a48b1ad7306626ca302
Source dataset
uspto-grants-2011_06
Patent number
US07968550B2

Reaction notes

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