HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2426749Generated: October 29, 2026
Potassium Phosphate, Tribasic → Methyl 4'-hydroxy-2,2',6'-trimethylbiphenyl-3-carboxylate
https://huagongshe.com/reaction/2426749
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 4-Bromo-3,5-dimethylphenol | HCID 81970 | — |
| Reactant | 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl | HCID 11269872 | — |
| Reactant | Methyl 2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate | HCID 57422592 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Methyl 4'-hydroxy-2,2',6'-trimethylbiphenyl-3-carboxylate | HCID 57787600 | — |
Reaction Steps
In an atmosphere of nitrogen, a mixture of methyl 2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, 4-bromo-3,5-dimethylphenol, palladium acetate, dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine, tripotassium phosphate, toluene and water was stirred for 14.5 hours with heating at 60° C. to obtain methyl 4′-hydroxy-2,2′,6′-trimethylbiphenyl-3-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07968552B2 |
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| Source dataset | uspto-grants-2011_06 |
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| ORD ID | ord-4b9230ad3ec74be0a8c4abb1ed5496be |
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| Source note | uspto-grants-2011_06 |
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