Sodium borohydride → 4′-Chloro-2′-methyl[1,1′-biphenyl]-3-methanol

HRID 2426750Notes

Reaction equation

HRID 2426750 reaction equation
[BH4-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH:16]=[O:17])[CH:11]=2)=[C:6]([CH3:18])[CH:5]=1>C(O)C>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH2:16][OH:17])[CH:11]=2)=[C:6]([CH3:18])[CH:5]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 86632832HCID 86632832, compound

Product 1

HCID 598551374′-Chloro-2′-methyl[1,1′-biphenyl]-3-methanol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In an atmosphere of nitrogen, under ice-cooling, sodium borohydride was added to an ethanol solution of 4′-chloro-2′-methylbiphenyl-3-carbaldehyde, followed by stirring for 1 hour to obtain (4′-chloro-2′-methylbiphenyl-3-yl)methanol.

Workup

  1. temperatureIn an atmosphere of nitrogen, under ice-cooling

Sources & evidence

ORD record
ord-5056cb66d01244229a13c6c04a5c3a0f
Source dataset
uspto-grants-2011_06
Patent number
US07968552B2

Reaction notes

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