Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 1-(3-Hydroxypropyl)pyrrolidin-2-one | HCID 566744 | — |
| Reactant | HCID 57787477 | HCID 57787477 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 57787132 | HCID 57787132 | — |
Reaction Steps
Methanesulfonyl chloride was dropwise added to a mixture of 1-(3-hydroxypropyl)pyrrolidin-2-one, triethylamine and ethyl acetate under ice-cooling, followed by stirring at 0° C. for 2 hours to obtain a colorless oil. 4-[(4′-Hydroxy-2′,6′-dimethylbiphenyl-3-yl)methoxy]benzaldehyde, cesium carbonate and DMF were added to the resulting oil, followed by stirring with heating at 60° C. for 19 hours to obtain 4-({2′,6′-dimethyl-4′-[3-(2-oxopyrrolidin-1-yl)propoxy]biphenyl-3-yl}methoxy)benzaldehyde.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07968552B2 |
|---|
| Source dataset | uspto-grants-2011_06 |
|---|
| ORD ID | ord-5ab3374b879649f48b905b1338ba7942 |
|---|
| Source note | uspto-grants-2011_06 |
|---|
