Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | HCID 57787795 | HCID 57787795 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 57787848 | HCID 57787848 | — |
Reaction Steps
A 4 M hydrogen chloride ethyl acetate solution was dropwise added under ice-cooling to an ethyl acetate solution of tert-butyl [2-({3′-[(4-formylphenoxy)methyl]-2,6-dimethylbiphenyl-4-yl}oxy)ethyl]carbamate, followed by stirring at 0° C. for 2 hours. Dichloromethane, acetyl chloride and triethylamine were added to the resulting compound, followed by stirring at room temperature for 12 hours to obtain N-[2-({3′-[(4-formylphenoxy)methyl]-2,6-dimethylbiphenyl-4-yl}oxy)ethyl]acetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07968552B2 |
|---|
| Source dataset | uspto-grants-2011_06 |
|---|
| ORD ID | ord-8cf7f0fff79e4fef90c808c2044884b5 |
|---|
| Source note | uspto-grants-2011_06 |
|---|
