Sodium cyanoborohydride → HCID 86632835, compound

Participants

Reaction Steps

Hydroxylamine hydrochloride and a sodium acetate aqueous solution were added to an ethanol solution of 4-[(4′-chloro-2′-methylbiphenyl-3-yl)methoxy]benzaldehyde, followed by stirring at room temperature for 18 hours to obtain 4-[(4-{[tert-butyl(dimethyl)silyl]oxy}-2′,6′-dimethylbiphenyl-3-yl)methoxy]benzaldehyde oxime. Sodium cyanoborohydride was added to a methanol-THF mixed solution of the resulting 4-[(4-{[tert-butyl(dimethyl)silyl]oxy}-2′,6′-dimethylbiphenyl-3-yl)methoxy]benzaldehyde oxime, and then a 4 M hydrogen chloride dioxane solution was dropwise added thereto, followed by stirring at room temperature for 1 hour to obtain N-{4-[(4-{[tert-butyl(dimethyl)silyl]oxy}-2′,6′-dimethylbiphenyl-3-yl)methoxy]benzyl)hydroxylamine.

Provenance & Evidence