HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 57422597, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Methyl-4-[(4-methylbenzenesulfonyl)oxy]butan-2-ol | HCID 14001295 | — |
| Reactant | HCID 178429280 | HCID 178429280 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57422597 | HCID 57422597 | — |
| Product | 5-bromo-1-(3-hydroxy-3-methylbutyl)-4-methylpyridin-2(1H)-one | HCID 57422598 | — |
Reaction Steps
In an atmosphere of nitrogen, sodium hydride was added under ice-cooling to a mixture of 5-bromo-4-methylpyridin-2-ol and DMF, followed by stirring at room temperature for 1 hour. Then, 3-hydroxy-3-methylbutyl 4-methylbenzenesulfonate was added thereto, followed by stirring at 40° C. for 14 hours to obtain 4-[(5-bromo-4-methylpyridin-2-yl)oxy]2-methylbutan-2-ol and 5-bromo-1-(3-hydroxy-3-methylbutyl)-4-methylpyridin-2(1H)-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07968552B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-c2916366ee204a46a7cc614a309bdfab |
| Source note | uspto-grants-2011_06 |