HCID 67147423, compound → HCID 67147576, compound

Participants

Reaction Steps

(2-{5,6-Dimethoxy-3-(1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]-pyridin-2-yl)indol-1-yl}ethyl)-(2-methoxyethyl)methylamine trifluoroacetate (0.0152 g; 22.46 μmol) is dissolved in a methanolic potassium hydroxide solution (0.5 ml; 0.1 g of potassium hydroxide/ml methanol) and then agitated at ambient temperature for 48 hours. After evaporation, the residue is taken up, with agitation, in 0.7 ml of a dimethyl sulfoxide and 12N aqueous hydrochloric acid (50/50 v/v). After returning to ambient temperature, dimethyl sulfoxide (0.35 ml) is added and then purification is carried out by reverse-phase liquid chromatography mass spectrometry (method B). The fractions containing the expected compound are combined and evaporated. {2-[5,6-Dimethoxy-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)indol-1-yl]ethyl}-(2-methoxyethyl)methylamine trifluoroacetate (0.0094 g; 80%) is isolated, the characteristics of which are as follows:

Provenance & Evidence