Potassium Hydroxide → HCID 67147433, compound

HRID 2426825Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]([CH2:14][CH2:15][C:16]([O:18]C)=[O:17])[CH:7]=[C:6]2[C:20]1[N:28](S(C2C=CC(C)=CC=2)(=O)=O)[C:23]2=[N:24][CH:25]=[CH:26][CH:27]=[C:22]2[CH:21]=1.[OH-].[K+]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])[CH:7]=[C:6]2[C:20]1[NH:28][C:23]2=[N:24][CH:25]=[CH:26][CH:27]=[C:22]2[CH:21]=1

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 67147578HCID 67147578, compound

Product 1

HCID 67147433HCID 67147433, compoundYield 87.8%

Procedure

3-[5,6-Dimethoxy-3-(1H-pyrrolo[2,3-b]pyridine-2-yl)indol-1-yl]propionic acid is prepared by following the procedure described in example 88a, but using 1 g of methyl 3-[5,6-dimethoxy-3-(1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)indol-1-yl]propionate and a solution of 74 ml of methanolic potassium hydroxide (0.1 g/ml; 1.78M). 0.601 g of 3-[5,6-dimethoxy-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)indol-1-yl]propionic acid is obtained, the characteristics of which are as follows:

Workup

custom3-[5,6-Dimethoxy-3-(1H-pyrrolo[2,3-b]pyridine-2-yl)indol-1-yl]propionic acid is prepared

Sources & evidence

ORD record: ord-5c5df59bf8b4456c9d38e2863841c418
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07968566B2

Reaction notes

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