N-Iodosuccinimide → 2-Amino-5-fluoro-3-iodopyridine

HRID 2426849Notes

Reaction equation

HRID 2426849 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.[I:9]N1C(=O)CCC1=O>C(O)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([I:9])[C:5]([NH2:8])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 27377012-Amino-5-fluoropyridine

Product 1

HCID 184559742-Amino-5-fluoro-3-iodopyridineYield 57.5%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

But using 5 g of 5-fluoropyridin-2-ylamine and 11.04 g of N-iodosuccinimide in 250 ml of glacial acetic acid. 6.1 g of 5-fluoro-3-iodopyridin-2-ylamine are thus obtained in the form of a solid, the characteristics of which are as follows:

Sources & evidence

ORD record
ord-0acbdcdf6c2444c69593bdcbd1450153
Source dataset
uspto-grants-2011_06
Patent number
US07968566B2

Reaction notes

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