反应详情

2-[5-Methoxy-6-(2-hydroxyethoxy)-1-methyl-1H-indol-3-yl]-1H-pyrrolo[2,3-b]pyridine is prepared by following the procedure as described in example 89a, but using 0.5 g of 2-[5-methoxy-6-(2-acetyloxyethoxy)-1-methyl-1H-indol-3-yl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine and 8.43 ml of a 5N aqueous potassium hydroxide solution. After purification by flash-pack chromatography (silica, 95/05 by volume dichloromethane/methanol as eluents, argon), 0.103 g of 2-[5-methoxy-6-(2-hydroxyethoxy)-1-methyl-1H-indol-3-yl]-1H-pyrrolo[2,3-b]pyridine is obtained, the characteristics of which are as follows:

1. custom2-[5-Methoxy-6-(2-hydroxyethoxy)-1-methyl-1H-indol-3-yl]-1H-pyrrolo[2,3-b]pyridine is prepared
2. customAfter purification by flash-pack chromatography (silica, 95/05 by volume dichloromethane/methanol as eluents, argon)