1,4'-Bipiperidine → HCID 67147489, compound

HRID 2426889Notes

Reaction equation

[N:1]1([CH:7]2[CH2:12]CNCC2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:13][C:14]1[CH:19]=[CH:18][N:17]=[C:16]2[N:20]([S:39]([C:42]3[CH:47]=[CH:46][C:45]([CH3:48])=[CH:44][CH:43]=3)(=[O:41])=[O:40])[C:21]([C:23]3[C:31]4[C:26](=[CH:27][C:28]([O:34]CCI)=[C:29]([O:32][CH3:33])[CH:30]=4)[N:25]([CH3:38])[CH:24]=3)=[CH:22][C:15]=12>>[Cl:13][C:14]1[CH:19]=[CH:18][N:17]=[C:16]2[N:20]([S:39]([C:42]3[CH:47]=[CH:46][C:45]([CH3:48])=[CH:44][CH:43]=3)(=[O:40])=[O:41])[C:21]([C:23]3[C:31]4[C:26](=[CH:27][C:28]([O:34][CH2:12][CH2:7][N:1]5[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]5[CH:4]5[CH2:5][CH2:6][NH:1][CH2:2][CH2:3]5)=[C:29]([O:32][CH3:33])[CH:30]=4)[N:25]([CH3:38])[CH:24]=3)=[CH:22][C:15]=12

Participants

Reactant 2

HCID 786071,4'-Bipiperidine

HCID 67147672HCID 67147672, compound

Product 1

HCID 67147489HCID 67147489, compoundYield 97.6%

Procedure

4-Chloro-2-[1-methyl-5-methoxy-6-(2-(4-piperidylpiperidin-1-yl)ethoxy)-1H-indol-3-yl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine is prepared by following the procedure described in example 147b, but using 0.212 g of 4-piperidinopiperidine and 0.400 g of 4-chloro-2-[1-methyl-5-methoxy-6-(2-iodoethoxy)-1H-indol-3-yl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine. 0.415 g of 4-chloro-2-[1-methyl-5-methoxy-6-(2-(4-piperidylpiperidin-1-yl)ethoxy)-1H-indol-3-yl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine is obtained, the characteristics of which are as follows:

Workup

custom4-Chloro-2-[1-methyl-5-methoxy-6-(2-(4-piperidylpiperidin-1-yl)ethoxy)-1H-indol-3-yl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine is prepared

Sources & evidence

ORD record: ord-252b59d341d34236877fb2bef7b95612
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07968566B2

Reaction notes

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